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Topical copper peptides for skin have been formulated at concentrations ranging from 0.1% to 3%, with most human clinical trials using 0.51% concentrations

The purified peptide is then treated with a copper salt (like copper sulfate) in a process called chelation, where the copper ion binds strongly to the peptide, forming the copper peptide complex

A randomized, double-blind, placebo-controlled phase 2 study comparing the efficacy and safety of tirzepatide versus placebo in 196 patients with nonalcoholic steatohepatitis (SYNERGY-NASH) with or without diabetes is currently underway and is estimated to complete in 2024